10/11 Rheumatism ratio of 400
10/15 Upadacitinib, Abatacept Go Head to Head in RA
10/16 EULAR Publishes Definition for Difficult-to-Treat RA
09/23 Aspirin May Be Considered for Primary Prevention of Cardiovascular Disease in Rheumatic Diseases
10/19 Sinovac Test Subjects Fall Ill; Tested Negative for Covid-19
10/14 Op-Ed: Cannabis Will Not Solve the Opioid Problem
10/18 Best of the Mess from Oct. 15, 1970
10/19 Can Copper Cure Pain?
10/16 Pharmacologic Management of Type 2 Diabetes May Improve Symptoms of Concurrent Polymyalgia Rheumatica
09/21 Long-term hydroxychloroquine use in patients with rheumatic conditions and development of SARS-CoV-2 infection: a retrospective cohort study
10/19 Vetiver Oil Market Size & Share, Global Market Research and Industry Forecast Report, 2027 (Includes Business Impact of COVID-19)
02/12 What is the Difference Between Arthritis and Rheumatism?
10/15 Rheumatic Diseases: Types, Symptoms, and Causes
05/06 Anti-rheumatism drug could help those with severe COVID-19 signs : The Asahi Shimbun
06/17 Early and intensive treatment of rheumatoid arthritis reduces fatigue
06/08 The European League Against Rheumatism, EULAR, launches Virtual Research Centre
06/30 Moving the diagosis of rheumatic diseases into the era of precision medicine
06/03 Navidea Biopharmaceuticals Announces Acceptance of Abstract for Presentation at the European League Against Rheumatism (EULAR) Congress
06/05 Thrombosis risk particularly high for people suffering from rheumatic and musculoskeletal disease activity
04/24 Controversy persists for palindromic rheumatism: RA precursor or distinct entity?
07/07 Treatment with methotrexate and risk of lung disease in patients with rheumatoid arthritis
10/07 6 ways to lower uric acid levels naturally
06/04 Majority of Patients With Rheumatic Conditions Recover From COVID-19 Regardless of Rheumatic Disease Therapy
07/17 Inflammatory rheumatism: Types, symptoms, and treatments
07/10 How COVID-19 lockdown has impacted people with arthritis
04/16 Rheumatic disease and COVID-19: initial data from the COVID-19 Global Rheumatology Alliance provider registries
06/30 Joint cell finding gives clues for improved treatment of rheumatoid arthritis
06/10 Rheumatoid arthritis drug shows promise against COVID-19, study finds
06/03 Study on COVID-19 and RMD provides reassurance to patients on immunosuppressive medication
06/04 Filgotinib Demonstrates Durable Efficacy and Consistent Safety Profile at 52 Weeks in FINCH 1 and 3 Studies in Rheumatoid Arthritis
06/08 Alpine Immune Sciences Provides Clinical Update of its Phase 1 Trial of ALPN-101 in Healthy Volunteers at the European League Against Rheumatism (EULAR) E-Congress 2020
10/18 Ossotide Injections Market Size, Share, Statistics, Demand and Revenue, Forecast 2025
06/09 Rheumatic disease in the context of COVID-19
11/18 Rheumatism Center / Krampe Schmidt Architects BDA
04/24 COVID-19-linked changes reported in rheumatic disease patient care
03/16 Expert Advice on Coronavirus Risk in Immunocompromised Patients With Rheumatic Diseases
10/14 COVID may deepen the hidden human and economic cost of arthritis
08/19 Conservative osteoarthritis therapy programme delays need for knee and hip joint replacement surgery
04/29 How lockdown impacts those with bone, joint and muscle pain
07/21 High-dose glucocorticoids and IL-6 receptor inhibition reduce COVID-19-associated cytokine storm mortality
06/05 Active Conventional Therapy Linked to High, Early Remission Rates in Rheumatoid Arthritis
05/22 High Prevalence of Rheumatic Regional Pain Syndromes in First-Degree Relatives of Patients with Rheumatoid Arthritis
08/04 Ankylosing spondylitis (AS): Becoming a mother despite having a rheumatic disease?
03/17 A protein that controls inflammation
06/10 Deployment of health care professionals can improve inflammatory-rheumatic disorders
05/13 Rheumatology visit within 6 weeks of RA symptom onset increases chance for remission
06/18 Patients with rheumatic disease, COVID-19 more likely to require ventilation
07/07 Heart Disease Often Missed in Rheumatoid Arthritis
05/13 EULAR 2020
01/20 Ultrasound could help reduce the use of drugs for patients with rheumatoid arthritis
06/05 Juvenile Idiopathic Arthritis Associated With Autism Spectrum Condition Diagnosis
09/12 Palindromic rheumatism: What it is, symptoms, and outlook
10/16 Pharma-grade Synthetic Camphor Market Market 2020 Industry Opportunities And Development Analysis 2026 : Merck KGaA, Oriental Aromatics Limited, Saptagir Camphor Limited, Mangalam Organics Limited
04/17 From the throat to the heart: Charting the long history of rheumatic fever
06/05 Interferon Inhibition With Anifrolumab Reduces Disease Activity in Systemic Lupus Erythematosus
08/04 Canakinumab shows promise for treatment of large joint osteoarthritis
03/31 EULAR launches COVID-19 RMD reporting database as part of Global Rheumatology Alliance
01/21 Proteins that protect against joint inflammation identified
06/15 EULAR Provides COVID-19 Recommendations
07/06 New vitamin K-based drug shows promise against medication-resistant epilepsy
11/14 The Many Benefits of, and Barriers to, Exercise in Patients With Rheumatologic Diseases
07/27 Here's what we know so far about the long-term symptoms of COVID-19
05/15 Rituximab Effectively Treats ‘Forerunner’ of RA
03/03 Cancer drugs shed light on rheumatism
04/02 Management of Sjögren's syndrome with topical and systemic therapies
12/19 Treating rheumatism and related syndromes with acupuncture
04/13 Hydroxychloroquine shortages related to COVID-19 may force ethical dilemma for rheumatologists
06/19 Study finds link between hoarding and ADHD
06/09 Upadacitinib Looks Effective for Psoriatic Arthritis
05/05 L-thyroxine does not improve subclinical hypothyroidism in those 65 or older
07/17 Rheum Round-up: Arthritis Medication Updates ? A New Methotrexate?, Tocilizumab In COVID-19
10/24 AbbVie draws favorable rating for its rheumatism drug in Europe
06/06 New option for treating active rheumatoid arthritis
02/10 Tocilizumab in isolated polymyalgia rheumatica: A systematic literature review
09/08 China seeks therapy for rheumatism with traditional Chinese medicine
10/10 Lars Jaeger: ?The Future is Veggie, With 3D Printing?
04/16 Study: Antibiotic and 'crapsule' therapy eliminate need for further treatment of Crohn's disease
11/10 Some people with RA treated with immune checkpoint inhibitors for cancer have flare, most able to continue treatment
07/04 Left untreated, arthritis can affect organs, lower life expectancy
10/12 Explained: Latest research on drugs, vaccines being repurposed for coronavirus
01/29 One step closer to tailored treatment of severe rheumatic diseases
03/30 How Clinicians Can Manage Rheumatic and Immune Diseases During COVID-19
04/02 New SLE Classification Criteria
04/03 Palm trees can help cure headaches, rheumatism
10/19 Global Pharma-grade Synthetic Camphor Market 2020 Regional Industry Growth Analysis, Size, Share, Outlook and Forecast Report by 2026 | Merck KGaA, Oriental Aromatics Limited, Saptagir Camphor Limited, Mangalam Organics Limited
09/15 Wen Xiong, MD, FACR, a Rheumatologist with Humane Center for Arthritis and Rheumatism
04/01 The Prescription for Rheumatism Used to Be to Sit Inside a Rotting Whale for 30 Hours
10/24 Smartphone study shows pain more likely on humid, windy days
10/01 How a plant-based diet can ease rheumatoid arthritis
10/16 Are There Benefits to Drinking Kombucha?
05/22 Corbus Pharmaceuticals Announces Publication of Two Abstracts at EULAR 2020 E-Congress
06/14 Patient organization challenges government to bring vital support to people with rheumatic diseases in Cyprus
11/10 Methotrexate reduces joint damage progression over placebo in erosive hand OA
03/07 Rheumatology Conference: South Carolina Rheumatism Society 2019 Annual Meeting
10/12 Why Cyprus makes for a perfect autumn holiday in the sun
09/11 2019 EULAR/ACR Recommendations for SLE Classification Criteria
12/18 Top 12 Rheumatology Books of 2019
07/23 Novel rheumatoid arthritis drug succeeds in clinical trial led by Stanford investigator
12/05 Rheumatism treatment effective even when the use of biological agents is slightly delayed


  • 「リウマチ」、「リューマチ」、「リュウマチ」、「ロイマチ」とよばれます。
  • 英語では、"Rheumatism", "Rheuma" と表記します。
  • からだのあちこちの関節に炎症が起こり、関節が腫れて痛む病気です。
  • 進行すると関節の変形や機能障害(使えなくなること)が起こります。
  • おもに、下の2つが代表的な疾患とされます。
    • 関節リウマチ と、
    • リウマチ熱




病院 医院、
周辺地図をみる 現在地を記憶する 現在地をリセット

関節リウマチ ( Rheumatoid Arthritis, RA )

関節リウマチ ( Rheumatoid Arthritis, RA )
関節リウマチ(Rheumatoid Arthritis:RA)は、自己の免疫が主に手足の関節を侵し、これにより関節痛、関節の変形が生じる代表的な膠原病の一つで、炎症性自己免疫疾患です。


  • 完全には病気の原因は究明されていません。
  • 自己の免疫系(細菌などから体を防御するシステム)に異常があることが知られています。
  • 免疫細胞が攻撃を始める根本原因は不明です。
    • 遺伝的なもの(遺伝子が関係する)
    • 感染した微生物(ウイルスや細菌)の影響
    • 妊娠や出産など女性ホルモンの変化


  • 朝のこわばりが、少なくとも1時間以上にわたってみられる
  • 3つ以上の関節に炎症による腫れがみられる
  • 手首や手指のつけ根の関節、手指の第2関節に炎症による腫れがみられる
  • 左右対称の関節に炎症による腫れがみられる
  • 皮下結節(リウマトイド結節)がひじやひざなどにみられる
  • 血液検査でリウマトイド因子が陽性である
  • X線検査で手の関節に骨の萎縮などの変化がみられる

  • 関節の痛み、腫れがある
  • 特に朝に、関節がこわばる
  • 多くの関節に症状がある(3か所〜程度)
  • 左右対称に症状がある(例:右手指と左手指)


  • 関節炎
    • 初期の症状「朝のこわばり(morning stiffness)」
    • そのうち、関節痛がおこるようになり、手指や足指の関節がおかされ、次第に手首、肘、膝など体の中心に近い大きな関節の痛みを感じるようになります。
    • 関節痛は、手を動かすなど活動すると増強します。
    • 関節炎が進行すると、関節そのものが変性し、最終的には関節が破壊し尽くされ、骨と骨が直接接した強直という状態になります。
    • 手足の関節の他では、胸・腰の背骨はおかされないが首の背骨(頚椎)はおかされやすいようです。
    • 頚部痛を生じたり、脊髄損傷、また、鎖骨に関節痛が起こる事もあります。
  • 血管

  • 関節リウマチ患者には、ドライアイもよく見られ、目の内側にリウマトイド結節が生じることもあります。
  • 呼吸器
  • 心臓
  • 神経
  • 皮膚
  • 血液


現在の治療指針では関節リウマチの診断がついたら、出来るだけ早期に抗リウマチ薬(DMARDs), 生物学的製剤を用いることが推奨されています。


  • DMARDs(抗リウマチ薬)
    関節リウマチの病気の勢いそのものを弱める薬として、メトトレキサート(リウマトレックス®)、スルファサラジン(アザルフィジン®)、 ブシラミン(リマチル®)、レフルノミド(アラバ®)、ミゾリビン、タクロリムス(プログラフ®)が使用されます。
  • ステロイド
    臨床試験の結果、ステロイドもDMARDsと同様に、病気の進行を遅らせる効果を示すことがわかり、DMARDsのみよりもDMARDsにステロイドを加えたほうが 病気の進行をさらに遅らせるという研究結果も報告されています。
  • 抗サイトカイン療法
    これらはリウマチに対してきわめて強力な治療効果を示していますが、これらの薬剤は免疫応答に対する抑制効果が強く、しばしば感染症を引き起こすことがあり、 抗菌薬の併用などによる十分な予防を行う必要があります。
  • その他の研究段階の新しい治療法
    悪性リンパ腫に効果のあるリツキシマブ(リツキサン®)、抗生剤であるテトラサイクリン、高脂血症治療薬であるスタチン、多発性骨髄腫治療薬であるサリドマイドの効果や、 造血幹細胞移植の効果も検討されています。
  • ビオチン治療法
    今までは、免疫不全症の原因が不明であることから、対処療法薬の投与をおこなう寛解維持療法がおこなわれていましたが、昨今の研究で、免疫不全症の一部の原因が初めて特定され、 これにより、ビオチン治療が確立しました。

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